Oxozeaenol, (5E)-7-
Oxozeaenol, (5E)-7-
$225.00 - 1 mg
$790.00 - 5 mg
All prices in Australian dollars
- Code
- BIA-O1897
- Synonyms
- f 152 B1, iso-LL Z1640-2
- CAS #
- 1198574-97-8
- Molecular Formula
- C19H22O7
- Molecular Weight
- 362.37
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in ethanol, methanol, DMF or DMSO.
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Application Notes
(5E)-7-Oxozeaenol ("iso-LL Z1640-2") is a resorcylic acid lactone belonging to the zearalenone class, recognised as a minor metabolite of the fungus, Drechslera portulacae. (5E)-7-Oxozeaenol was rediscovered as a major analogue of a resorcylic acid lactone complex from a Phoma-related species by Pierce and colleagues in 2011. (5E)-7-Oxozeaenol is the double bond isomer of LL Z1640-2 ((5Z)-7-oxozeaenol), a selective TAK 1 inhibitor. (5E)-7-Oxozeaenol exhibits moderate anti-tumor activity and NF-KB inhibitory activity but is otherwise unexplored.
References
- Zearalenone derivatives produced by the fungus Drechslera portulacae. Sugawara F. et al., Phytochem. 1992, 31, 1987.
- Resorcylic acid lactones with cytotoxic and NF-KB inhibitory activities and their structure-activity relationships. Ayers S. et al., J. Nat. Prod. 2011, 74, 1126.