Oligomycin B

Oligomycin B

$150.00 - 5 mg

$525.00 - 25 mg

All prices in Australian dollars

Code
BIA-O1060
CAS #
11050-94-5
Molecular Formula
C45H72O12
Molecular Weight
805.1
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Oligomycin B, a minor component of the oligomycin complex isolated from selected strains of Streptomyces, is an inhibitor of mitochondrial F1F0-ATPase. It makes cells more susceptible to cell death, and also leads to a switch in the death mode from apoptosis to necrosis.

References

  • Age-dependent cell death and the role of ATP in hydrogen peroxide-induced apoptosis and necrosis. Miyoshi N. et al., Proc. Natl Acad. Sci. USA 2006, 103, 1727.
  • Mitochondria in eosinophils: functional role in apoptosis but not respiration. Peachman K.K. et al., Proc. Natl Acad. Sci. USA 2001, 98, 1717.
  • The BH3 domain is required for caspase-independent cell death induced by Bax and oligomycin. Fitch M.E. et al., Cell Death Differ. 2000, 7, 338.

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