Novobiocic acid

Novobiocic acid

$215.00 - 0.50 mg

$755.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-N1881
CAS #
485-23-4
Molecular Formula
C22H21NO6
Molecular Weight
395.41
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Novobiocic acid is a member of the novobiocin aminocoumarin antibiotic family. Novobiocic acid is a key intermediate in the biosynthesis of novobiocin and an important acid degradation product. While novobiocic acid exhibits little antibacterial activity, it is more potent than novobiocin as a potentiator of etoposide BP-16 activity by inhibiting efflux from tumor cells.

References

  • Initial characterization of novobiocic acid noviosyl transferase activity of NovM in biosynthesis of the antibiotic novobiocin. Freel Meyers C.L. et al., Biochem. 2003, 42, 4179.
  • Novobiocic acid synthetase. Koinek LA. & Meyer H.F., Meth. enzymol. 1975, 43, 502.
  • Structure-activity studies of novobiocin analogs as modulators of the cytotoxicity of etoposide (VP-16). Rappa G. et al., Oncol. Res. 2000, 12, 113.

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