Norstictic acid was first reported in 1934 as a metabolite produced by the lichen, Lobaria pulmonaria, along with two related compounds. Norstictic acid has antioxidant, antimicrobial and antitumor activities. Norstictic acid treatment significantly suppresses MDA-MB-231/GFP tumor growth of a breast cancer xenograft model in athymic nude mice.
- Lichen substances. XXXIX. A new lichen acid, norstictinic acid, and the occurrence of d-arabitol in lichens. Asahina Y. & Yanagita M., Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen 1934, 67B, 799.
- Biological activities of Toninia candida and Usnea barbata together with their norstictic acid and usnic acid constituents. Rankovic B. et al., Int. J. Mol. Sci. 2012, 13, 14797.
- Norstictic acid inhibits breast cancer cell proliferation, migration, invasion, and in vivo invasive growth through targeting C-Met. Ebrahim H.Y. et al., Phytother. Res. 2016 30, 557.