Mitorubrinic acid was isolated from the phytotoxic fungus, Penicillium funiculosum. Mitorubrinic acid was patented in Japan in 1996 as a dihydrofolate reductase inhibitor for the treatment of protozoal diseases. Mitorubrinic acid shows weak inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH). Mitorubrinic acid inhibits trypsin with an IC50 41 µmol/l.
- Mitorubrinic acid and related compounds from a strain of Penicillium funiculosum. Locci R. et al. Gioron Microbiol. 1967, 15, 92.
- Dihydrofolate reductase inhibitors containing mitorubrin compounds for protozoiasis. Hayashi K. et al. JP08217673 A 1996-08-27.
- Microbial inhibitors active against Plasmodium falciparum dihydroorotate dehydrogenase derived from an Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979. Pramisandi A. et al. J Gen Appl Microbiol. 2020, 66, 273.