Mitorubrinic acid

Mitorubrinic acid

$250.00 - 1 mg

$875.00 - 5 mg

All prices in Australian dollars

Code
BIA-M2969
CAS #
58958-07-9
Molecular Formula
C21H16O9
Molecular Weight
412.35
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Mitorubrinic acid was isolated from the phytotoxic fungus, Penicillium funiculosum. Mitorubrinic acid was patented in Japan in 1996 as a dihydrofolate reductase inhibitor for the treatment of protozoal diseases. Mitorubrinic acid shows weak inhibitory activity against Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH). Mitorubrinic acid inhibits trypsin with an IC50 41 µmol/l.

References

  • Mitorubrinic acid and related compounds from a strain of Penicillium funiculosum. Locci R. et al. Gioron Microbiol. 1967, 15, 92.
  • Dihydrofolate reductase inhibitors containing mitorubrin compounds for protozoiasis. Hayashi K. et al. JP08217673 A 1996-08-27.
  • Microbial inhibitors active against Plasmodium falciparum dihydroorotate dehydrogenase derived from an Indonesian soil fungus, Talaromyces pinophilus BioMCC-f.T.3979. Pramisandi A. et al. J Gen Appl Microbiol. 2020, 66, 273.

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