Lovastatin

Lovastatin

$195.00 - 25 mg

$55.00 - 5 mg

All prices in Australian dollars

Code
BIA-L1264
Synonyms
Mevinolin, Monacolin K, L 154803, MB 530B, MSD 803
CAS #
75330-75-5
Molecular Formula
C24H36O5
Molecular Weight
404.5
Purity
>95% by HPLC
Long Term Storage
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Lovastatin (mevinolin) is a metabolite first isolated from Monascus ruber and later found in several other fungal species. Lovastatin is a potent inhibitor of HMG-CoA. HMG-CoA reductase is the rate-controlling enzyme of the mevalonate pathway, responsible for the biosynthesis of cholesterol. Lovastatin was developed as a drug as a hypolipemic agent.

References

  • Monacolin K, a new hypocholesterolemic agent produced by a Monascus species. Endo A. J. Antibiot. 1979, 32, 852.
  • Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase. Endo A. J. Antibiot. 1980, 33, 334.
  • Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Alberts A. W. et al., Proc. Natl. Acad. Sci. U.S.A. 1980, 77, 3957.

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