Lobaric acid is a hydrophobic orcinol depsidone found in a broad range of lichen species, notably within the genera, Stereocaulon and Parmelia, first reported by Asahina and Nonamura in 1935. Like many other lichen acids, lobaric acid displays a broad pharmacology. Most recently, lobaric acid was shown to inhibit cysteinyl-leukotriene formation leading to muscle contraction in Taenia coli and type 12(S)-lipoxygenase, and to interfere with protein-protein interactions. Lobaric acid is an important standard in the chemotaxonomy of lichens.
- Untersuchungen uber flechtenstoffe, LVI. Mitteil.: Uber die konstitution der lobarsaure (I. Mitteil.). Asahina Y. and Nonomura S., Ber. Dtsch. Chem. Ges. 1935, 68, 1698.
- Effect of lobaric acid on cysteinyl-leukotriene formation and contractile activity of guinea pig Taenia coli. Gissurarson S.R. et al., J. Pharmacol. Exp.Therap. 1997, 280, 770.
- Sekikaic acid and lobaric acid target a dynamic interface of the coactivator CBP/p300. Majmudar C.Y. et al., Angew. Chem. Int. Ed. 2012, 51, 11258.
- A catalogue of standardized chromatographic data and biosynthetic relationships for lichen substances. Elix J., 2014, Third Edition. Published by the author, Canberra, Australia.