Kreysigine ((-)-kreysigine) was first isolated from Kreysigia multiflora, a member of the Liliacaeae family, in 1960 by Badger and Bradbury, University of Adelaide, Australia. Kreysigine and its analogue floramultine can be biosynthesised in Kreysigia multiflora shoots treated with autumnaline in vivo by direct coupling. Kreysigine causes dose dependent relaxation of rat ileal smooth muscle (EC50 5.7×10-5 M), which could be mediated through the elevation of intracellular cyclic nucleotides, eventually decreasing cytosolic calcium concentration. Kreysigine reduces gastrointestinal motility.