IT-143-A is a rare, higher homologue of the piericidin class isolated from a Streptomyces sp. by Taiho Pharmaceuticals in collaboration with Chinese researchers in 1996. IT-143-A is active against the fungus, Aspergillus fumigatus, and the Gram-positive bacterium, Micrococcus luteus. IT-143-A is also active against KB carcinoma cells. Lack of availability until now has hindered exploration of its pharmacological effects.
- IT-143-A and B, novel piericidin-group antibiotics produced by Streptomyces sp. Urakawa A. et al., J. Antibiot. 1996, 49, 1052.
- Antibacterial, antifungal, and antitumor IT-143 substance of Streptomyces sp. Urakawa A. et al., Jpn. Kokai Tokkyo Koho 1997, JP 09249647.