Illudin M

Illudin M

$280.00 - 1 mg

$980.00 - 5 mg

All prices in Australian dollars

Code
BIA-I1685
Synonyms
Illudine M; NSC 400978; NSC 626370
CAS #
1146-04-9
Molecular Formula
C15H20O3
Molecular Weight
248.32
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

Download Data Sheets

Product Data Sheet

Application Notes

Illudin M is sesquiterpene isolated as the toxic principle from the basidiomycete, Clitocybe illudens (Omphalotus illudens, Jack O’lantern) by McMorris and Anchel, New York Botanical Gardens in 1965. The total synthesis of illudin M was completed by Kinder and Blair in 1994. Illudin M has potent and selective activity against mammalian tumor cells and its potential as an in vivo antitumor was intensively investigated. Illudin M acts as a bifunctional alkylating agent, reacting spontaneously with thiols, notably, glutathione or cysteine at or slightly below pH 7.

References

  • Fungal metabolites. The structures of the novel sesquiterpenoids illudin-S and -M. McMorris T.C. and Anchel M., J. Am. Chem. Soc. 1965, 87, 1594.
  • Structure-activity relationships of illudins: analogs with improved therapeutic index. McMorris T.C. et al., J. Org. Chem. 1992, 57, 6876.
  • Total synthesis of (+)-illudin M. Kinder F.R. and Blair K.W. et al., J.O.C., 1994, 59, 6965.

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