Hydroxy-L-tyrosine methyl ester, 3-

Hydroxy-L-tyrosine methyl ester, 3-

$51.00 - 5 mg

$179.00 - 25 mg

All prices in Australian dollars

Code
BIA-H2603
Synonyms
3,4-Dihydroxyphenyl-L-alanine methyl ester hydrochloride, 3-Hydroxy-L-tyrosine methyl ester hydrochloride, L-DOPA Me ester hydrochloride, L-Dopa methyl ester hydrochloride, Levodopa methyl ester hydrochloride, Methyl L-3-(3,4-dihydroxyphenyl)alaninate hydrochloride, ST 41769
CAS #
1421-65-4
Molecular Formula
C10H13NO4
Molecular Weight
211.2
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

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Application Notes

3-Hydroxy-L-tyrosine methyl ester (melevodopa, L-dopa methyl ester) is a prodrug of levodopa used for the treatment of Parkinson’s disease. L-​DOPA methyl ester is a potent competitive antagonist for the action of L-​DOPA. Short-term exposure to L-​DOPA methyl ester inhibits the induction of endogenous xenotropic type-​C virus from Kirsten sarcoma-​virus-​transformed BALB​/c (K-​BALB) mouse cells. L-​DOPA methyl ester has weak activity against against L1210 and P388 murine leukaemias and B-16 melanoma cell lines.

References

  • Available and emerging treatments for Parkinson’s disease: a review. Drug Design Dev. 2011, 5, 241.
  • L-​dopa methyl ester antagonizes competitively L-​dopa-​induced facilitation of noradrenaline release from rat hypothalamic slices. Goshima Y. et al. Japan J Pharmacol. 1990, 52, 174.
  • Inhibition of endogenous murine retrovirus expression by L-​β-​3,​4-​dihydroxyphenylalanine (L-​dopa) methyl ester. Suk W.A. et al. Int J Cancer 1981, 27, 37. 

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