The hodgkinsines are indole alkaloids from Hodgkinsonia frutescens (family Rubiaceae) containing three linked tryptamine units. Hodkinsine was first reported by Ritchie and co-workers, University of Sydney, in 1961. Hodgkinsineshows potent dose-dependent analgesic activity against capsaicin-induced pain, with low affinity for mu opioid receptors. Hodgkinsine has a broad bioprofile with potent antimicrobial activity, antifungal and cytotoxic activity. Hodgkinsine has substantial antiviral activity against DNA viruses and is a platelet aggregation inhibitor.
- Hodgkinsine, the alkaloid of Hodgkinsonia frutescens. Anet E.F.L.J. et al. Aust J Chem. 1961, 14, 173.
- Antinociception profile of hodgkinsine. Amado T.A. et al. Planta Med. 2000, 66, 770.
- Biological activities of pyrrolidinoindoline alkaloids from Calycodendron milnei. Saad H.E. et al. Planta Med. 1995, 61, 313.