Hodgkinsine

Hodgkinsine

$233.00 - 1 mg

$816.00 - 5 mg

All prices in Australian dollars

Code
BIA-H1948
Synonyms
(-)-Hodgkinsine
CAS #
18210-71-4
Molecular Formula
C33H38N6
Molecular Weight
518.7
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

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Application Notes

The hodgkinsines are indole alkaloids from Hodgkinsonia frutescens (family Rubiaceae) containing three linked tryptamine units. Hodkinsine was first reported by Ritchie and co-workers, University of Sydney, in 1961. Hodgkinsineshows potent dose-​dependent analgesic activity against capsaicin-​induced pain, with low affinity for mu opioid receptors. Hodgkinsine has a broad bioprofile with potent antimicrobial activity, antifungal and cytotoxic activity. Hodgkinsine has substantial antiviral activity against DNA viruses and is a platelet aggregation inhibitor.

References

  • Hodgkinsine, the alkaloid of Hodgkinsonia frutescens. Anet E.F.L.J. et al. Aust J Chem. 1961, 14, 173.
  • Antinociception profile of hodgkinsine. Amado T.A. et al. Planta Med. 2000, 66, 770.
  • Biological activities of pyrrolidinoindoline alkaloids from Calycodendron milnei. Saad H.E. et al. Planta Med. 1995, 61, 313.

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