Graphislactone A is the major analogue of a family of phenolic benzopyranones isolated from a mycobiont of lichens of the genus Graphis, first reported by Japanese researchers at Kobe Pharmaceutical University in 1997. Graphislactone A protects against oxidative injury by dose-dependent free radical scavenging and antioxidant activity.
- Four phenolics from the cultured lichen mycobiont of Graphis scripa var. pulverulenta. Tanahashi T. et al., Chem. Pharm. Bull. 1997, 45, 1183.
- 6H-dibenzo[b,d]pyran-6-one derivatives from the cultured lichen mycobionts of Graphis spp. and their biosynthetic origin. Tanahashi T. et al., Phytochemistry 2003, 62, 71.
- Characterization of graphislactone A as the antioxidant and free radical-scavenging substance for the culture of cephalosporium sp. IFB-E001, an endophytic fungus in Trachelospermum jasminoides. Song Y.C. et al., Biol. Pharm. Bull. 2005, 28, 506.