Gilvocarcin V

Gilvocarcin V

$302.00 - 0.50 mg

$1,057.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-G1035
Synonyms
Anandimycin A, Toromycin, 1072B
CAS #
77879-90-4
Molecular Formula
C27H26O9
Molecular Weight
494.5
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.

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Application Notes

Gilvocarcin V is the major analogue of a complex of C-glycoside antitumor actives isolated from a Streptomyces sp. Gilvocarcin V contains a vinyl group in the 8-position, and is the most potent analogue of the complex. It is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. The metabolite displays potent antibacterial, antifungal, antiviral and antitumor activity. Recent research suggests that the gilvocarcins act as photoactivated cross-linkers of DNA to histones.

References

  • Antitumor agents from Streptomyces anandii: gilvocarcins V, M and E. Balitz D.M. et al., J Antibiot (Tokyo) 1981, 34, 1544-1555.
  • Activation of antitumor agent gilvocarcins by visible light. Elespuru R.K. & Gonda S.K. Science 1984, 223, 69.
  • Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated gilvocarcin V in human fibroblasts. Matsumoto A. & Hanawalt P.C. Cancer Res. 2000, 60, 3921.

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