Galiellalactone

Galiellalactone

$302.00 - 1 mg

$1,057.00 - 5 mg

All prices in Australian dollars

Code
BIA-G1032
CAS #
133613-71-5
Molecular Formula
C11H14O3
Molecular Weight
194.2
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

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Application Notes

Galiellalactone was originally isolated from Galiella rufa as a plant growth regulator. Recently it was shown to inhibit IL-6 induced SEAP expression with IC50 values of 250-500 nM, blocking the binding of the activated Stat3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation of the Stat3 transcription factor.

References

  • The high-intrinsic Diels-Alder reactivity of (-)-galiellalactone; generating four quaternary carbon centers under mild monditions, von Nussbaum F. et al., Eur. J. Org. Chem. 2004, 2783.
  • Biologically active secondary metabolites from the ascomycete A111-95. 1. Production, isolation and biological activities. Kopcke B. et al., J. Antibiot. 2002, 55, 36.
  • Synthesis of (-)-galiellalactone. Johansson M. et al., J. Antibiot. 2002, 55, 663.
  • Screening of basidiomycetes and ascomycetes for plant growth regulating substances. R. Hautzel & H. Anke, Z. Naturforsch. 1990, 45c, 1094.

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