Galiellalactone was originally isolated from Galiella rufa as a plant growth regulator. Recently it was shown to inhibit IL-6 induced SEAP expression with IC50 values of 250-500 nM, blocking the binding of the activated Stat3 dimers to their DNA binding sites without inhibiting the tyrosine and serine phosphorylation of the Stat3 transcription factor.
- The high-intrinsic Diels-Alder reactivity of (-)-galiellalactone; generating four quaternary carbon centers under mild monditions, von Nussbaum F. et al., Eur. J. Org. Chem. 2004, 2783.
- Biologically active secondary metabolites from the ascomycete A111-95. 1. Production, isolation and biological activities. Kopcke B. et al., J. Antibiot. 2002, 55, 36.
- Synthesis of (-)-galiellalactone. Johansson M. et al., J. Antibiot. 2002, 55, 663.
- Screening of basidiomycetes and ascomycetes for plant growth regulating substances. R. Hautzel & H. Anke, Z. Naturforsch. 1990, 45c, 1094.