Filipin II

Filipin II

$300.00 - 0.50 mg

$1,050.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-F1615
CAS #
38620-77-8
Molecular Formula
C35H58O10
Molecular Weight
638.8
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Application Notes

Filipin II is a minor component of the filipin complex, a family of pentaene antifungal metabolites first isolated from Streptomyces filipinensis and reported by researchers at Upjohn in 1955. Structurally, filipin II lacks the hydroxy moiety on the pentyl side chain and is more hydrophobic, eluting later than filipin III on reverse phase HPLC. Filipin II is a potent broad spectrum antifungal agent that also exhibits antitumor and antiviral activities and acts by binding cell membrane sterols, disrupting membrane integrity.

References

  • Filipin, an antifungal antibiotic: Isolation and properties. Whitfield G.B. et al., J. Am. Chem. Soc. 1955, 77, 4799.
  • Separation of polyene antifungal antibiotics by high speed liquid chromatography. Mechlinski W. & Schaffner C.P. J. Chromatogr. 1974, 99, 619.
  • Inhibition of fungi by filipin and its antagonism by sterols. Gottlieb D. et al., Phytopathology 1960, 50, 594.

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