Fervenulin, structurally related to caffeine, was first isolated from Streptomyces fervens in 1959 and reported as a broad spectrum antibiotic, with antineoplastic properties. Fervenulin inhibits egg hatch and increases juvenile mortality of the root-knot nematode Meloidogyne incognita in vitro, killing up to 100% of second-stage nematode juveniles when applied at a concentration of 250 µg/mL.
- Fervenulin, a new crystalline antibiotic I. Discovery and biological activities. Deboer C. et al. Antibiot Ann. 1959 – 1960, 7, 227.
- Free radical mechanisms of action of pyrimidotriazine antibiotics. Orlov V.S. et al. Bioorganicheskaya Khimiya 1983, 9, 556.
- Nematicidal activity of fervenulin isolated from a nematicidal actinomycete, Streptomyces sp. CMU-MH021, on Meloidogyne incognita. Ruanpanun P. et al. World J Microbiol Biotech. 2011, 27, 1373.