Feglymycin is an amphoteric, 13-member, linear peptide featuring 3,5-dihydroxyphenylalanine and a terminal dicarboxylate amino acid, isolated from a Streptomyces in 1999. Feglymycin is a potent antiviral agent with antibacterial activity, including against MRSA. Feglymycin specifically inhibits the enzymes MurA and MurC and inhibits cell-to-cell transfer between HIV-infected T cells, uninfected CD4+ T cells, and the DC-SIGN-mediated viral transfer to CD4+ T cells.
- Feglymycin, a novel inhibitor of the replication of the human immunodeficiency virus. Fermentation, isolation and structure elucidation. Vértesy L. et al., J. Antibiot. 1999, 52, 374.
- Feglymycin is an inhibitor of the enzymes MurA and MurC of the peptidoglycan biosynthesis pathway. Rausch S. et al., Chembiochem. 2011, 12, 1171.
- Feglymycin, a unique natural bacterial antibiotic peptide, inhibits HIV entry by targeting the viral envelope protein gp120. Férir G. Virology 2012, 433, 308.