Feglymycin

Feglymycin

$315.00 - 1 mg

$1,105.00 - 5 mg

All prices in Australian dollars

Code
BIA-F1420
CAS #
209335-49-9
Molecular Formula
C95H97N13O30
Molecular Weight
1900.9
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Feglymycin is an amphoteric, 13-member, linear peptide featuring 3,5-dihydroxyphenylalanine and a terminal dicarboxylate amino acid, isolated from a Streptomyces in 1999. Feglymycin is a potent antiviral agent with antibacterial activity, including against MRSA. Feglymycin specifically inhibits the enzymes MurA and MurC and inhibits cell-to-cell transfer between HIV-infected T cells, uninfected CD4+ T cells, and the DC-SIGN-mediated viral transfer to CD4+ T cells.

References

  • Feglymycin, a novel inhibitor of the replication of the human immunodeficiency virus. Fermentation, isolation and structure elucidation. Vértesy L. et al., J. Antibiot. 1999, 52, 374.
  • Feglymycin is an inhibitor of the enzymes MurA and MurC of the peptidoglycan biosynthesis pathway. Rausch S. et al., Chembiochem. 2011, 12, 1171.
  • Feglymycin, a unique natural bacterial antibiotic peptide, inhibits HIV entry by targeting the viral envelope protein gp120. Férir G. Virology 2012, 433, 308.

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