Enopeptin A

Enopeptin A

Enopeptin A

$335.00 - 0.5 mg

$1,175.00 - 2.5 mg

All prices in Australian dollars

Code
BIA-E1555
Synonyms
Enopeptin II, BRN 5373924, NSC657143
CAS #
139601-96-0
Molecular Formula
C47H57N7O11
Molecular Weight
896
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol, DMSO.

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Product Data Sheet

Application Notes

Enopeptin A is an unusual depsipeptide featuring a pentaenone side chain, reported as an antiviral by researchers at RIKEN in 1991. Enopeptin A has potent antibacterial activity against Gram positive and Gram negative bacteria, including MRSA. Enopeptin A is the most non-polar of the acyldepsipeptide (ADEP) antibiotics which include the recently rediscovered compounds, A54556 A and B, that act by activating and disregulating Clp-family proteins.

References

  • The structure of enopeptins A and B, novel depsipeptide antibiotics. Koshino H. et al., Tetrahedron Letters 1991, 32, 7707.
  • Enopeptin A, a novel depsipeptide antibiotic with anti-bacteriophage activity. Osada H. et al., J. Antibiot. 1991, 44, 1436.
  • Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Lee B-G. et al., Nature Struct. Mol. Biol. 2010, 17, 471.

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