$96.00 - 5 mg
$336.00 - 25 mg
All prices in Australian dollars
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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Dirithromycin is a macrolide antibiotic pro-drug of 9S-erythromycylamine, a close analogue of erythromycin in which the 9-keto group is replaced with an amino group in the S-configuration. Although erythromycylamine overcomes the acid instability of erythromycin, it is poorly absorbed following oral administration. Dirithromycin is formed by reacting erythromycylamine with an aldehyde to form a Schiff base which undergoes cyclisation to an oxazine with the C11-alcohol. Dirithromycin provides higher tissue levels and prolonged in vivo half-life by slowly releasing erythromycylamine.
- Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136: LY237216), a new macrolide antibiotic derived from erythromycin. Counter F.T. et al., Antimicrob. Agents Chemother. 1991, 35, 1116.
- Dirithromycin: Introduction and historical development. Kirst H.A. Drugs Today 1995, 31, 89.