Dihydrocyclosporin A

Dihydrocyclosporin A

$150.00 - 1 mg

$525.00 - 5 mg

All prices in Australian dollars

Code
BIA-D1252
CAS #
59865-15-5
Molecular Formula
C62H113N11O12
Molecular Weight
1204.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

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Product Data Sheet

Application Notes

Dihydrocyclosporin A is a closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A possesses no immunosuppressant activity and has found use as a control to determine the role of immunosuppression in the pharmacology of cyclosporin A, particularly in the treatment of parasitic infections.

References

  • Isolation and identification of a novel human metabolite of cyclosporin A: dihydro-CsA M17. Meier G. P. et al., Drug Metab Dispos. 1990, 18, 68.
  • Dosage, timing, and route of administration of cyclosporin A and nonimmunosuppressive derivatives of dihydrocyclosporin A and cyclosporin C against Schistosoma mansoni in vivo and in vitro. Chappell L. H. et al., Antimicrob Agents Chemother. 1987, 31, 1567.
  • Action of cyclosporin A on the tapeworms Hymenolepis microstoma, H. diminuta and Mesocestoides corti in vivo. Chappell L. H. et al., Parasitology. 1989, 98, 291.

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