Dihydrocyclosporin A
Dihydrocyclosporin A
$150.00 - 1 mg
$525.00 - 5 mg
All prices in Australian dollars
- Code
- BIA-D1252
- CAS #
- 59865-15-5
- Molecular Formula
- C62H113N11O12
- Molecular Weight
- 1204.6
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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Application Notes
Dihydrocyclosporin A is a closely related co-metabolite of cyclosporin A. Dihydrocyclosporin A possesses no immunosuppressant activity and has found use as a control to determine the role of immunosuppression in the pharmacology of cyclosporin A, particularly in the treatment of parasitic infections.
References
- Isolation and identification of a novel human metabolite of cyclosporin A: dihydro-CsA M17. Meier G. P. et al., Drug Metab Dispos. 1990, 18, 68.
- Dosage, timing, and route of administration of cyclosporin A and nonimmunosuppressive derivatives of dihydrocyclosporin A and cyclosporin C against Schistosoma mansoni in vivo and in vitro. Chappell L. H. et al., Antimicrob Agents Chemother. 1987, 31, 1567.
- Action of cyclosporin A on the tapeworms Hymenolepis microstoma, H. diminuta and Mesocestoides corti in vivo. Chappell L. H. et al., Parasitology. 1989, 98, 291.
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