The cyclic hexapeptide, desotamide, was first isolated from a Streptomyces sp. found to produce salinamide A, an inhibitor of bacterial RNA polymerase. Little is known of desotamide's intrinsic activity or potency.
- Inhibition of bacterial RNA polymerases. Peptide metabolites from the cultures of Streptomyces sp. Shichang M. et al., J. Nat. Prod.1997, 60, 858.