Cycloheximide
Cycloheximide
$70.00 - 5 mg
$245.00 - 25 mg
All prices in Australian dollars
- Code
- BIA-C1415
- Synonyms
- Actidione, Naramycin, U 4527, NSC 185
- CAS #
- 66-81-9
- Molecular Formula
- C15H23NO4
- Molecular Weight
- 281.4
- Purity
- >95% by HPLC
- Long Term Storage
- -20°C
- Solubility
- Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
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Application Notes
Cycloheximide is the most recognised member of the glutarimide microbial metabolites. Cycloheximide was isolated from Streptomyces griseus in the late 1940s as a potent and broad spectrum antifungal. Cycloheximide inhibits protein synthesis by interfering with translocation. Cycloheximide is an established bioprobe and widely-used antifungal reagent in research with over 25,000 literature citations.
References
- Antibiotic substance isolated from the beers of streptomycin-producing strains of Streptomyces griseus. Leach B.E. et al., J. Am. Chem. Soc. 1947, 69, 474.
- The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes. Obrig T.G. et al., J. Biol. Chem. 1971, 246, 174.