Cycloheximide

Cycloheximide

$70.00 - 5 mg

$245.00 - 25 mg

All prices in Australian dollars

Code
BIA-C1415
Synonyms
Actidione, Naramycin, U 4527, NSC 185
CAS #
66-81-9
Molecular Formula
C15H23NO4
Molecular Weight
281.4
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.

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Product Data Sheet

Application Notes

Cycloheximide is the most recognised member of the glutarimide microbial metabolites. Cycloheximide was isolated from Streptomyces griseus in the late 1940s as a potent and broad spectrum antifungal. Cycloheximide inhibits protein synthesis by interfering with translocation. Cycloheximide is an established bioprobe and widely-used antifungal reagent in research with over 25,000 literature citations.

References

  • Antibiotic substance isolated from the beers of streptomycin-producing strains of Streptomyces griseus. Leach B.E. et al., J. Am. Chem. Soc. 1947, 69, 474.
  • The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes. Obrig T.G. et al., J. Biol. Chem. 1971, 246, 174.

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