Cinnabarinic acid

Cinnabarinic acid

$150.00 - 0.10 mg

$525.00 - 0.50 mg

All prices in Australian dollars

Code
BIA-C2356
Synonyms
Cinnabaric acid, Cinnavalininic acid
CAS #
606-59-7
Molecular Formula
C14H8N2O6
Molecular Weight
300.22
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

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Product Data Sheet

Application Notes

Cinnabarinic acid is an endogenous kynurenine metabolite formed from oxidative dimerization of 3-​hydroxyanthranilic acid and transamination of 3-​hydroxykynurenine. Cinnabarinic acid activates glutamate receptors by interacting with residues of the glutamate binding pocket of mGlu4. Cinnabarinic acid induces apoptosis in T cells through generation of reactive oxygen species, the loss of mitochondrial membrane potential and caspase activation.

References

  • Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors. Fazio F. et al. Mol Pharmacol. 2012, 81, 643.
  • Effects of cinnabarinic acid on mitochondrial respiration. Zollner H. Biochem Pharmacol. 1976, 2, 643.
  • Cinnabarinic acid generated from 3-​hydroxyanthranilic acid strongly induces apoptosis in thymocytes through the generation of reactive oxygen species and the induction of caspase. Hariamatsu R. et al. J Cell Biochem. 2008, 103, 42.

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