Capreomycin sulfate

Capreomycin sulfate

$70.00 - 5 mg

$245.00 - 25 mg

All prices in Australian dollars

Code
BIA-C1455
Synonyms
Caprocin
CAS #
1405-37-4
Molecular Formula
C25H48N14O13S2 (for IB)
Molecular Weight
816.9 (for IB)
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Good water solubility.

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Application Notes

Capreomycin sulfate is a salt of a complex of cyclic pentopeptides isolated from Streptomyces capreolus, first reported in 1962. The sulfate salt is the most commonly accessible formulation of capreomycin and is used for pharmaceutical applications. The complex has two major components, IA and IB, with an exocyclic lysine residue and two minor delysinyl components, IIA and IIB. Capreomycin is a potent antibiotic with activity against mycobateria, Gram positive and Gram negative organisms. Capreomycin acts by binding to the 23S ribosomal subunit, disrupting protein synthesis.

References

  • Chemical and biological properties of capreomycin and other peptide antibiotics. Herr E.B. Antimicrob. Agents Chemother. 1962, 1963, 201.
  • Molecular basis for the selectivity of antituberculosis compounds capreomycin and viomycin. Akbergenov R. et al., Antimicrob. Agents Chemother. 2011, 55, 4712.

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