Aszonalenin

Aszonalenin

$209.00 - 1 mg

$732.00 - 5 mg

All prices in Australian dollars

Code
BIA-A1686
Synonyms
Aszonalenine; NSC 374337
CAS #
81797-27-5
Molecular Formula
C23H23N3O2
Molecular Weight
373.45
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
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Application Notes

Aszonalenin is a complex benzodiazepine metabolite isolated from Aspergillus zonatus by Kimura and co-workers at Tottori University, Japan in 1982. Structurally, aszonalenin is formed from an intra-molecular ring closure of anthranilic acid and L-tryptophan to form the pyrrole, followed by prenylation. At high concentration aszonalenin has been shown to induce an abnormal second cleavage of sea urchin embryos but its pharmacology has otherwise received scant attention.

References

  • Structure of aszonalenin, a new metabolite of Aspergillus zonatus. Kimura Y., Tet. Lett. 1982, 23, 225.
  • The synthesis of (-)-dihydroaszonalenin from L-tryptophan; the relative and absolute configuration of aszonalenin. Bhat B. and Harrison D.M., Tetrahedron 1993, 49, 10655.
  • Stereospecific synthesis of aszonalenins by using two recombinant prenyltransferases. Yin W-B. et al., Org. Biomol. Chem., 2009, 7, 2202.

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