Asterric Acid

Asterric Acid

$245.00 - 1 mg

$858.00 - 5 mg

All prices in Australian dollars

Code
BIA-A1008
Synonyms
Dimethylosoic acid, TAN 1415A, WF 12880A
CAS #
577-64-0
Molecular Formula
C17H16O8
Molecular Weight
348.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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Application Notes

Asterric acid is a fungal metabolite with anti-angiogenic properties, isolated from a number of Aspergillus and Penicillium species. It is an inhibitor of vascular endothelial growth factor (VEGF), inhibiting VEGF-induced tube formation of human umbilical vein endothelial cells.

References

  • Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs. Lee H.J. et al., J. Antibiot. 2002, 55, 552.
  • Asterric acid, a new endothelin binding inhibitor. Ohashi H. et al., J. Antibiot. 1992, 45, 1684.
  • Studies in the biochemistry of micro-organisms. 115. Metabolites of Penicillium frequentans Westling: isolation of sulochrin, asterric acid, (+)-bisdechlorogeodin and two new substituted anthraquinones, questin and questinol. Mahmoodian A. et al., Biochem. J. 1964, 92, 369.

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