Aspochalasin D

Aspochalasin D

$209.00 - 1 mg

$732.00 - 5 mg

All prices in Australian dollars

Code
BIA-A1642
CAS #
71968-02-0
Molecular Formula
C24H35NO4
Molecular Weight
401.54
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
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Application Notes

Aspochalasin D is a potent inhibitor of mammalian tumor cell lines, first isolated from Aspergillus microcysticus by Keller-Schierlein and co-worker in 1979. While known to be an epimer of aspochalasin C, the stereochemistry was not resolved until Hayakawa and co-workers at University of Tokyo re-isolated the metabolite as a selective apoptosis inducer in Ras-dependent pathways in 2001.

References

  • Stoffwechselprodukte von Mikroorganismen. Uber die Aspochalasine A, B, C und D. Keller-Schierlein W. and Kupfer E., Helv. Chim. Acta 1979, 62, 1501.
  • Selective cytotoxicity and stereochemistry of aspochalasin D. Tomikawa T. et al., J. Antibiot. 2001, 54, 379.

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