Aspochalasin D is a potent inhibitor of mammalian tumor cell lines, first isolated from Aspergillus microcysticus by Keller-Schierlein and co-worker in 1979. While known to be an epimer of aspochalasin C, the stereochemistry was not resolved until Hayakawa and co-workers at University of Tokyo re-isolated the metabolite as a selective apoptosis inducer in Ras-dependent pathways in 2001.
- Stoffwechselprodukte von Mikroorganismen. Uber die Aspochalasine A, B, C und D. Keller-Schierlein W. and Kupfer E., Helv. Chim. Acta 1979, 62, 1501.
- Selective cytotoxicity and stereochemistry of aspochalasin D. Tomikawa T. et al., J. Antibiot. 2001, 54, 379.