Asiatic acid

Asiatic acid

$50.00 - 25 mg

$176.00 - 100 mg

All prices in Australian dollars

Code
BIA-A2673
Synonyms
2α,3β,23-Trihydroxyurs-12-en-28-oic acid, Dammarolic acid, NSC 166063
CAS #
464-92-6
Molecular Formula
C30H48O5
Molecular Weight
488.7
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
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Application Notes

Asiatic acid is a pentacyclic triterpene abundant in many medicinal plants first published in the 1950s. Asiatic acid has broad biological activity including inhibition of human collagen I synthesis and neuro- and cardioprotective effects. Asiatic acid induces aproptosis through activation of extracellular signal-​regulated kinase and p38 mitogen-​activated protein kinase pathways in human breast cancer cells.

References

  • A reinvestigation of the triterpenes of Centella asiatica. Singh B. & Rastogi R.P. Phytochem. 1969, 8, 917.
  • Influence of asiatic acid, madecassic acid, and asiaticoside on human collagen I synthesis. Bonte F. et al. Planta medica 1994, 60, 133.
  • Structure-​activity relationship study of asiatic acid derivatives against beta amyloid (A beta)​-​induced neurotoxicity. Jew S.S. et al. Bioorg Med Chem Lett. 2000, 10, 119.

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