Andrastin A

Andrastin A

$232.00 - 0.50 mg

$813.00 - 2.50 mg

All prices in Australian dollars

Code
BIA-A1649
Synonyms
NSC 697452
CAS #
174232-42-9
Molecular Formula
C28H38O7
Molecular Weight
486.6
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
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Application Notes

Andrastin A is potent inhibitor of protein farnesyltransferase (PFTase) isolated by Omura and co-workers at the Kitasato Institute, Japan in 1996. Andrastin A is a meroterpenoid with an androstane skeleton biosynthesized from a sesquiterpene and a tetraketide. The cyclopentane ring of andrastin A exhibits characteristic keto-enol tautomerism. Andrastin A is potently active against mammalian tumor cell lines and is devoid of antimicrobial activity.

References

  • Andrastins A ~ C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929.I. Producing strain, fermentation, isolation and biological activities. Omura S. et al., J. Antibiot. 1996, 49, 414.
  • Andrastins A ~ C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929.II. Structure elucidation and biosynthesis. Uchida R. et al., J. Antibiot. 1996, 49, 418.
  • Reconstituted biosynthesis of fungal meroterpenoid andrastin A. Matsuda Y. et al., Tetrahedron 2013, 69, 8199.

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