Aminoimidazole-4-carboxamide, 5-

Aminoimidazole-4-carboxamide, 5-

$180.00 - 5 mg

$630.00 - 25 mg

All prices in Australian dollars

Code
BIA-A2590
CAS #
360-97-4
Molecular Formula
C4H6N4O
Molecular Weight
126.1
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

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Product Data Sheet

Application Notes

5-Aminoimidazole-4-carboxamide is a ubiquitous metabolite and an intermediate in purine biosynthesis of compounds such as acadesine and gancyclovir. Derivatives of 5-aminoimidazole-4-carboxamide have broad biological effects as antitumor, antiviral, antidiabetic and anti-inflammatory agents. 5-Aminoimidazole-4-carboxamide derivatives activate AMP kinase.

References

  • Controls of nuclear factor-kappa B signaling activity by 5'-AMP-activated protein kinase activation With examples in human bladder cancer cells. Choi B-H. et al. Int Neurourol J 2016, 20, 182.
  • AMP-activated protein kinase and type 2 diabetes. Musi N. et al. Curr Med Chem 2006, 13, 583.
  • The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting. Hall D.T. et al. EMBO Mol Med 2018, 10, e8307.

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