A 54556B

A 54556B

$276.00 - 0.50 mg

$966.00 - 2.50 mg

All prices in Australian dollars

CAS #
95398-44-0
Molecular Formula
C37H48N6O8
Molecular Weight
704.8
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
Clear

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Application Notes

A 54556B is an unusual depsipeptide isolated from Streptomyces hawaiiensis as antibiotics by researchers at Eli Lilly in 1985, featuring a trienone side chain. A 54556B is a potent antibacterial against Gram positive and Gram negative bacteria including MRSA. A 54556B is a member of the recently re-discovered acyldepsipeptide (ADEP) antibiotics that act by activating and disregulating Clp-family proteins. ADEPs are considered important leads in the development of new generations of antibiotics against resistant bacteria.

References

  • A54556 antibiotics and process for production thereof. Michel K.H. and Kastner R.E. U.S. Patent 4,492,650 1985.
  • Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism. Lee B-G, et al, Nature Struct. Molec. Biol. 2010, 17, 471.
  • Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ. Sass P. et al., PNAS 2011, 108, 1747.

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