A 26771B

A 26771B

$275.00 - 1 mg

$965.00 - 5 mg

All prices in Australian dollars

Code
BIA-A1902
Synonyms
Antibiotic A 26771b, BPL 81
CAS #
56448-20-5
Molecular Formula
C20H30O7
Molecular Weight
382.45
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.

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Product Data Sheet

Application Notes

A 26771B is a 16-membered macrocyclic lactone isolated from Penicillium turbatum patented and then published by Eli Lilly and Co. in 1975. A 26771B is closely related to the berkeleylactones, recently reported as antibiotics derived from a co-fermentation of P. fuscum and P. camenbertii/clavigerum. A 26771B shows potent activity in vitro against Gram-positive bacteria and moderate activity against a broad selection of fungi. A 26771B inhibits potassium dependent ATPase in rat liver mitochondria.

References

  • The isolation and structure elucidation of macrocyclic lactone antibiotic, A26771B. Michel K.H. et al., J. Antibiot. 1977, 30, 571.
  • The berkeleylactones, antibiotic macrolides from fungal coculture. Stierle A.A. et al., J. Nat. Products 2017, 80, 1150.
  • Stereospecific total synthesis and absolute configuration of a macrocyclic lactone antibiotic, A26771B. Tatsuta K. et al., Tetrahedron Letters 1980, 21, 1479.

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