Zaragozic acid A

Zaragozic acid A

$155.00 - 1 mg

$543.00 - 5 mg

All prices in Australian dollars

Synonyms
Squalestatin A, Squalestatin S1, L 694599
CAS #
142561-96-4
Molecular Formula
C35H46O14
Molecular Weight
690.7
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Moderate water solubility.
Clear

Download Data Sheets

Application Notes

Zaragozic acid A is the major metabolite of a class of unusual bicyclic tricarboxylic acids, produced by a number of fungi in the genera Curvularia, Exserohilum, Setosphaeria and others, discovered at Merck and Glaxo in the early 1990s. In nature, zaragozic acid A acts as a broad spectrum antifungal but its mode of action as an inhibitor of squalene synthase, involved in sterol biosynthesis, led to investigation as a cholesterol lowering agent. Zaragozic acid A prepared by BioAustralis is presented as the free acid rather than the tri-sodium salt to avoid stability problems associated with hydrolysis of the salt.

References

  • The zaragozic acids. A family of fungal metabolites that are picomolar competitive inhibitors of squalene synthase. Bergstrom J.D. et al., Proc. Nat. Acad. Sci. 1993, 90, 80.
  • Distribution of zaragozic acids (squalestatins) among filamentous ascomycetes. Bills G.F. Mycol. Res. 1994, 98, 733-739.

Other Products