Voacamine

Voacamine

$132.00 - 1 mg

$463.00 - 5 mg

All prices in Australian dollars

Code
BIA-V1751
Synonyms
MMH 18, Malarex, NSC 82591, Voacanginine
CAS #
3371-85-5
Molecular Formula
C43H52N4O5
Molecular Weight
703.9
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
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Application Notes

Voacamine is an indole alkaloid derived from members of the Voacanga species, indigenous to Africa. In the Pacific region, voacamine was successfully isolated from the small tree, Voacanga papuana, indigenous to New Guinea by Ritchie and Taylor, University of Sydney, Australia in 1965. Voacamine enhances the cytotoxic effect of vinblastine against multidrug resistant KB cells. Voacamine enhances the cytotoxic effect of vinblastine against multidrug resistant KB cells, and is active against protozoa, including Plasmodium falciparum, Leishmania donovani and Trypanosoma cruzi, inhibiting protozoal topoisomerase IB.

References

  • Pharmacology of the alkaloids of Voacanga species. Quevauviller A. et al., Annales Pharmaceutiques Francaises 1955, 13, 423.
  • Some constituents of Rejoua aurantiaca Gaud. and Voacanga papuana (F. Muell.) K. Schum. Guise G.B. et al., Aust. J. Chem. 1965, 18, 927.
  • Indole alkaloids from Peschiera laeta that enhance vinblastine-mediated cytotoxicity with multidrug-resistant cells. You M. et al., J. Nat. Prod. 1994, 57, 1517.

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