Venturicidin A

Venturicidin A

$155.00 - 1 mg

$543.00 - 5 mg

All prices in Australian dollars

Synonyms
Aabomycin A1
CAS #
33538-71-5
Molecular Formula
C41H67NO11
Molecular Weight
750
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Clear

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Application Notes

The macrolide antibiotic, Venturicidin A, isolated from a Streptomyces sp., is a potent inhibitor of mitochondrial ATP synthase complex acting on the F0 membrane sector. Venturicidin A was originally isolated as an antifungal agent.

References

  • Studies on the mechanism of oxidative phosphorylation. ATP synthesis by submitochondrial particles inhibited at F0 by venturicidin and organotin compounds. Matsuno-Yagi A. & Hatefi Y. J. Biol. Chem. 1993, 268, 6168.
  • Potassium selective and venturicidin sensitive conductances of Fo purified from bovine heart mitochondria, reconstituted in planar lipid bilayers. Miedema H. et al., Biochem. Biophys. Res. Commun. 1994, 203, 1005.
  • Amino acid substitutions in mitochondrial ATP synthase subunit 9 of Saccharomyces cerevisiae leading to venturicidin or ossamycin resistance. Galanis M. et al., FEBS Lett. 1989, 249, 333.

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