Rubiginone D2 was isolated from a Streptomyces sp. by Zeeck and co-workers, University of Gottingen, Germany in 2000. Rubiginone D2 is an angucycline, an angular tetracyclic benzanthracene core containing a highly oxygenated A ring. Rubiginone D2 is a potent cytotoxic agent, demonstrating 50% inhibition of growth (GI50) of stomach adenocarcinoma HM02, colon carcinoma Kato III, hepatocellular carcinoma HEPG2 and breast adenocarcinoma MCF7 cell lines at concentrations of 0.1, 0.7, <0.1 and 7.5 µM, respectively.
- Angucyclines: Total syntheses, new structures, and biosynthetic studies of an emerging new class of antibiotics. Krohn K. & Rohr J. In Topics in current chemistry, Vol. 188. Biorganic chemistry. Ed., J. Rohr, pp. 127- 1 95, Springer-Verlag, Berlin-Heidelberg, 1997.
- New biologically active rubiginones from Streptomyces sp. Puder C. et al. J Antibiot. 2000, 53, 329.