Puromycin

Puromycin

$420.00 - 25 mg

$120.00 - 5 mg

All prices in Australian dollars

Code
BIA-P1230
Synonyms
Achromycin, Stillomycin, Stylomycin, CL 13900, 3123L, P638, Bacterenomycin
CAS #
53-79-2
Molecular Formula
C22H29N7O5
Molecular Weight
471.5
Purity
>95% by HPLC
Long Term Storage
Soluble in ethanol, methanol, DMF or DMSO. Moderate water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Puromycin is a nucleoside antibiotic isolated from Streptomyces alboniger in the 1950s as an anti-trypanosomal agent with antibiotic activity. Puromycin is non-selective, inhibiting RNA by blocking ribosomal translation. Puromycin is used in cell biology to select mammalian cell lines that have been transformed by vectors that express puromycin-N-acetyl-transferase.

References

  • Achromycin, the structure of the antibiotic puromycin. Waller C.W.J., Am. Chem. Soc. 1953, 75, 2025.
  • Biosynthesis of puromycin by Streptomyces alboniger. Characterization of puromycin N-acetyltransferase. Vara J. et al., Biochemistry 1985, 24, 8074.
  • Unexpected cytokinetic effects induced by puromycin include a G2- arrest, a metaphase-mitotic-arrest, and apoptosis. Davidoff A.N. & Mendelow B.V., Leuk. Res. 1992, 16, 1077.
  • Effect of puromycin analogues and other agents on peptidyl-puromycin synthesis on polyribosomes. Petska S. et al., Antimicrobial Agents Chemother. 1973, 4, 37.

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