Pleuromutilin

Pleuromutilin

$195.00 - 25 mg

$55.00 - 5 mg

All prices in Australian dollars

Code
BIA-P1204
Synonyms
Drosophilin B, A 40104C
CAS #
125-65-5
Molecular Formula
C22H34O5
Molecular Weight
378.5
Purity
>95% by HPLC
Long Term Storage
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.

Download Data Sheets

Application Notes

Pleuromutilin is a diterpene produced by several species of basidomycete, notably the genus Pleurotus, discovered in 1951. Pleuromutilin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action. Pleuromutilin inhibits protein synthesis by binding to domain V of 23S rRNA and this has led to the development of many semi-synthetic analogues as new generation antibiotics, such as tiamulin and retapamulin.

References

  • Antibiotic substances from basidomycetes. VIII. Pleurotus mutilus (Fr.) Sacc. & Pleurotus passeckerianus Pilat. Kavanagh F. et al., Proc. Natl. Acad. Sci. USA 1951, 37, 570.
  • Pleuromutilin antibiotics. Hunt E., Drugs Future 2000, 25, 1163.
  • Pleuromutilins. Part 1. The indentification of novel mutilin 14-carbamates. Brooks G. et al., Bioorg. Med. Chem. 2001, 9, 1221.

Other Products