$302.00 - 25 mg
$1,057.00 - 100 mg
All prices in Australian dollars
- Drosophilin B, A 40104C
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
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Pleuromutilin is a diterpene produced by several species of basidomycete, notably the genus Pleurotus, discovered in 1951. Pleuromutilin is a potent and highly selective antibiotic active against a range of Gram positive bacteria, with no cross resistance to existing antibiotic classes due to its unique mode of action. Pleuromutilin inhibits protein synthesis by binding to domain V of 23S rRNA and this has led to the development of many semi-synthetic analogues as new generation antibiotics, such as tiamulin and retapamulin.
- Antibiotic substances from basidomycetes. VIII. Pleurotus mutilus (Fr.) Sacc. & Pleurotus passeckerianus Pilat. Kavanagh F. et al., Proc. Natl. Acad. Sci. USA 1951, 37, 570.
- Pleuromutilin antibiotics. Hunt E., Drugs Future 2000, 25, 1163.
- Pleuromutilins. Part 1. The indentification of novel mutilin 14-carbamates. Brooks G. et al., Bioorg. Med. Chem. 2001, 9, 1221.