L-Phe-L-Pro (phenylalanylproline) is a dipeptide isolated from Streptomyces lavendulae no. 314. L-Phe-L-Pro is an incomplete breakdown product of protein catabolism. L-Phe-L-Pro demonstrates cholesterol-lowering activity in hypercholesterolemic rats via decreased ATP-binding cassette transporter A1 (ABCA1) expression in the rat jejunum and reduced cholesterol absorption in Caco-2 cells.
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- Identification of a novel cholesterol-lowering dipeptide, phenylalanine-proline (FP), and its down-regulation of intestinal ABCA1 in hypercholesterolemic rats and Caco-2 cells. Banno A. et al. Sci Rep. 2019, 9, 19416.