Oxanthromicin, (+)

Oxanthromicin, (+)

$199.00 - 0.25 mg

$697.00 - 1 mg

All prices in Australian dollars

CAS #
1616622-08-2
Molecular Formula
C36H30O12
Molecular Weight
654.62
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
Clear

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Application Notes

(+)-Oxanthromicin is an unusual dimeric anthrone co-produced with staurosporine by Streptomyces sp. MST-134270, reported by Capon and co-workers in 2014 as an inducer of the mislocalisation K-Ras on the cell membrane. (+)-Oxanthromicin was also found to act synergistically with staurosporine, a more potent active in this assay. (+)-Oxanthromicin is an enantiomer of (-)-oxanthromicin isolated from an Actinomadura sp. SCC 1646 by researchers at Schering as an antifungal and antibacterial in 1984.

References

  • Oxanthromicin, a novel antibiotic from Actinomadura. Patel M. et al., J. Antibiot. 1984, 37, 413.
  • Structure of oxanthromicin (antibiotic 16–550), a novel dimeric anthrone peroxide. Wright J.J.K. et al., J. Chem. Soc. Chem. Commun. 1984, 473.
  • Rare Streptomyces sp. polyketides as modulators of K-Ras localisation. Salim A.A. et al., Org. Biomol. Chem. 2014, 12, 4872.

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