Oxanthromicin, hemi-

Oxanthromicin, hemi-

$189.00 - 0.50 mg

$662.00 - 2.50 mg

All prices in Australian dollars

CAS #
91161-78-3
Molecular Formula
C18H16O6
Molecular Weight
328.3
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
Clear

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Application Notes

hemi-Oxanthromicin is the monomer of (±)-oxanthromicin, first isolated from a soil-derived Streptomyces sp. by Capon and co-workers in 2014. Unlike its co-metabolites, oxanthromicin and spiro-oxanthromicin, hemi-oxanthromicin does not inhibit mislocalisation of the oncogenic mutant K-Ras from the plasma membrane of intact Madin-Darby canine kidney (MDCK) cells. hemi-Oxanthromicin in assays for antibacterial, antiviral, antimycobacterial and phytopahtogenicl activity. hemi-Oxanthromicin shows minimal cytotoxicity.

References

  • Rare Streptomyces sp. polyketides as modulators of K-Ras localisation. Salim A. et al. Org Biomol Chem 2014, 12, 4872.
  • Anthrone derivatives from the terrestrial actinomycete, Actinomadura sp. BCC47066. Bunbamrunga N. et al. Phytochem Lett 2018, 25, 109. 

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