Ostreogrycin A

Ostreogrycin A

$325.00 - 5 mg

$1,140.00 - 25 mg

All prices in Australian dollars

Mikamycin A, Pristinamycin IIA, Stephylomycin M1, Streptogramin A, Syncothrecin A, Synergistin A1, Virginiamycin M1, Vernamycin A, 14752-2, E129A, PA 114A, 1745Z3A, 547C, Factor M
Molecular Formula
Molecular Weight
>95% by HPLC
Long Term Storage
Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol. Poor water solubility.

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Application Notes

Ostreogrycin A (virginiamycin M1, streptogramin A) is the major component of the virginiamycin complex. In the 1950s this complex was independently discovered so many times that the literature became highly confusing. Ostreogrycin A is a macrocyclic lactone antibiotic that acts synergistically with the structurally unrelated cyclic depsipeptides, virginiamycin B (ostreogrycin B, streptogramin B) and virginiamycin S, to inhibit peptide elongation. This is achieved by blocking formation of a peptide bond between the growing peptide chain (peptidyl-tRNA) linked to the 50S ribosome and aminoacyl-tRNA. Ostreogrycin A is highly active against Gram positive bacteria, particularly MRSA.


  • Preparation and properties of an antibiotic complex E129. Ball S. 1958, 68, 24P.
  • Virginiamycin: nomenclature. Crooy P. and De Neys R. J. Antibiot. 1972, 25, 371.
  • Sites of interaction of streptogramin A and B antibiotics in the peptidyl transferase loop of 23 S rRNA and the synergism of their inhibitory mechanisms. Porse B.T. and Garrett R.A.J. Mol. Biol. 1999, 286, 375.

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