Neosartoricin B

Neosartoricin B

$255.00 - 1 mg

$895.00 - 5 mg

All prices in Australian dollars

Code
BIA-N2533
CAS #
1421708-43-1
Molecular Formula
C24H26O8
Molecular Weight
442.5
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

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Product Data Sheet

Application Notes

Neosartoricin B was produced biosynthetically in 2013 by Tang and colleagues from UCLA USA by selecting the gene cluster for neosartoricin that is homologous to a conserved cluster among dermatophytes of the Trichophyton and Arthroderma genera. When integrated into the model Aspergillus nidulans host, a structurally related compound neosartoricin B was formed, suggesting a possible role of this compound in the pathogenesis of these strains. Neosartoricin B is the O-deacetyl analogue of neosartoricin A, an immunosuppressive agent.

References

  • Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans. Yin W-B et al. ACS Synth Biol 2013, 2, 629.
  • Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi. Chooi Y-H. et al. Org Lett 2013, 15, 780.

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