Neosartoricin B was produced biosynthetically in 2013 by Tang and colleagues from UCLA USA by selecting the gene cluster for neosartoricin that is homologous to a conserved cluster among dermatophytes of the Trichophyton and Arthroderma genera. When integrated into the model Aspergillus nidulans host, a structurally related compound neosartoricin B was formed, suggesting a possible role of this compound in the pathogenesis of these strains. Neosartoricin B is the O-deacetyl analogue of neosartoricin A, an immunosuppressive agent.
- Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans. Yin W-B et al. ACS Synth Biol 2013, 2, 629.
- Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi. Chooi Y-H. et al. Org Lett 2013, 15, 780.