Myxothiazol

Myxothiazol

$180.00 - 0.10 mg

$630.00 - 0.50 mg

All prices in Australian dollars

Code
BIA-M2449
Synonyms
(+)-Myxothiazol A, Myxothiazol A, Myxothiazole A
CAS #
76706-55-3
Molecular Formula
C25H33N3O3S2
Molecular Weight
487.68
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO

Download Data Sheets

Product Data Sheet

Application Notes

Myxothiazol is a secondary metabolite of Myxococcus fulvus active against fungi, in particular Trichophyton mentagrophytes, Pythium debaryanum and Picularia oryzae (MIC 0.02, 0.02 and 0.8 µg/mL). Myxothiazol is weakly active against some bacteria including Staphylococcus aureus (MIC 30~50 µg/mL). Myxothiazol is cytostatic when tested against Candida albicans, blocking oxygen consumption. Myxothiazol inhibits cAMP production and antagonises the activities of 3β-​hydroxysteroid dehydrogenase, 17α-​hydroxylase​/C17-​20 lyase and 17β-​hydroxysteroid dehydrogenase, as well as suppressing LH-​stimulated testosterone production in Leydig cells.

References

  • Myxothiazol, an antibiotic from Myxococcus fulvus (Mxyobacterales) I. Cultivation, isolation, physico-chemical and biological properties. Gerth K. et al. J Antibiot. 1980, 33, 1474 and 1480. 
  • Myxothiazol, a new antibiotic interfering with respiration. Thierbach G. and Reichenbach H. Antimicrob Agents Chemother. 1981, 19, 504.
  • Effect of myxothiazol on Leydig cell steroidogenesis: inhibition of luteinizing hormone-​mediated testosterone synthesis but stimulation of basal steroidogenesis. Midzak A.S. et al. Endocrinol. 2007, 148, 2583.

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