$51.00 - 5 mg
$179.00 - 25 mg
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- (2S)-2-Amino-3-(1-methyl-1H-imidazol-5-yl)propanoic acid, 3-Methylhistidine, 3-N-Methyl-L-histidine
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in methanol or DMSO
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3-Methyl-L-histidine is an L-histidine derivative substituted by a methyl group at postion 3 on the imidazole ring. 3-Methyl-L-histidine is an endogenous human metabolite and is also produced by Saccharomyces cerevisiae. 3-Methyl-L-histidine is formed by methylation of histidine as a posttranslational modification of actin and myosin. 3-Methyl-L-histidine is more abundant in in myosin from white skeletal muscle than from myosin of red skeletal and smooth muscle. 3-Methyl-L-histidine is a product of the degradation of myofibrillar proteins.
- Biological activity and the 3-methylhistidine content of actin and myosin. Johnson P. and Perry S.V. Biochem J. 1970, 119, 293.
- Plasma N tau-methylhistidine concentration is a sensitive index of myofibrillar protein degradation during starvation in rats. Nagasawa T. et al. Biosci Biotechnol Biochem. 1996, 60, 501.
- Comparison between 3-methylhistidine production and proteinase activity as measures of skeletal muscle breakdown in protein-deficient growing barrows. Van den Hemel-Grooten H.N.A. et al. J Animal Sci. 1995, 73, 2272.