Demethyl FR-901235, 9-
9-Demethyl FR-901235 was first isolated from an endophytic penicillium species in 2008 by Lin and colleagues from the Ocean University of China. 9-Demethyl FR-901235 has antitumor activity. FR-901235 itself is an immunomodulator reported to restore normal mitogen-induced lymphocyte proliferation after treatment with an immunosuppressive factor and to partially restore the impaired delayed-type hypersensitivity to sheep red blood cells in tumor-bearing mice. 9-Demethyl FR-901235 was recently reported as being co-produced with talauxins by Talaromyces stipitatus.
- Polyketides from Penicillium sp. JP-1, an endophytic fungus associated with the mangrove plant Aegiceras corniculatum. Lin Z. et al. Phytochem. 2008, 69, 1273.
- A new immunomodulator, FR-901235. Shibata T. et al. J Antibiot. 1989, 42,1356
- Talauxins: Hybrid phenalenone dimers from Talaromyces stipitatus. Chaudhary N.K. et al. J Nat Prod. 2020, 83, 1051.