Demethyl FR-901235, 9-

Demethyl FR-901235, 9-

$158.00 - 0.25 mg

$553.00 - 1 mg

All prices in Australian dollars

CAS #
1029520-85-1
Molecular Formula
C17H14O7
Molecular Weight
330.29
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol or DMSO
Clear

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Application Notes

9-Demethyl FR-901235 was first isolated from an endophytic penicillium species in 2008 by Lin and colleagues from the Ocean University of China. 9-Demethyl FR-901235 has antitumor activity. FR-901235 itself is an immunomodulator reported to restore normal mitogen-induced lymphocyte proliferation after treatment with an immunosuppressive factor and to partially restore the impaired delayed-type hypersensitivity to sheep red blood cells in tumor-bearing mice. 9-Demethyl FR-901235 was recently reported as being co-produced with talauxins by Talaromyces stipitatus.

References

  • Polyketides from Penicillium sp. JP-​1, an endophytic fungus associated with the mangrove plant Aegiceras corniculatum. Lin Z. et al. Phytochem. 2008, 69, 1273.
  • A new immunomodulator, FR-901235. Shibata T. et al. J Antibiot. 1989, 42,1356
  • Talauxins: Hybrid phenalenone dimers from Talaromyces stipitatus. Chaudhary N.K. et al.  J Nat Prod. 2020, 83, 1051.

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