Carboline 1-carboxylic acid, β-
β-Carboline 1-carboxylic acid, isolated from Quassia amara, displays antineuroinflammatory activity in lipopolysaccharide-induced BV2 microglial cells, inhibiting the production of nitric oxide and prostaglandin E2. Derivatives of β-carboline 1-carboxylic acid inhibit mitogen-activated protein kinase 2. β-Carboline 1-carboxylic acid is also formed endogenously from tryptophan.
- Anti-neuroinflammatory activities of indole alkaloids from kanjang (Korean fermented soy source) in lipopolysaccharide-induced BV2 microglial cells. Kim D-C. et al. Food Chem. 2016, 213, 69.
- Novel tetrahydro-beta-carboline-1-carboxylic acids as inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Trujillo J.I. et al. Bioorg Med Chem Lett. 2007, 17, 4657.
- Tetrahydro-beta-carboline-3-carboxylic acids and contaminants of L-tryptophan. Adachi A. et al. J Chromatogr A. 2000, 881, 501.