Benzomalvin A

Benzomalvin A

$233.00 - 1 mg

$816.00 - 5 mg

All prices in Australian dollars

Code
BIA-B1647
CAS #
157047-96-6
Molecular Formula
C24H19N3O2
Molecular Weight
381.43
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
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Application Notes

Benzomalvin A was isolated as an active inhibitor of substance P binding to mammalian neurokinin NK1 receptors by researchers at Sterling Winthrop Pharmaceuticals (now Sanofi Aventis). The core benzodiazepine structure of benzomalvin A is formed biosynthetically by the condensation of two molecules of anthranilic acid and a phenylalanine. Benzomalvin A is related to the asperlicins, potent and selective antagonists of peripheral cholecystokinin receptors. Lack of availability has hampered further exploration of the pharmacology of benzomalvin A.

References

  • Benzomalvins, new substance P inhibitors from a Penicillium sp. Sun H.H. et al., J. Antibiot. 1994, 47, 515.
  • The first total synthesis of (-)-benzomalvin A and benzomalvin B via the intramolecular aza-Wittig reactions. Sugimori T. et al., Tetrahedron 1998, 54, 7997.
  • Asperlicin, a novel non-peptidal cholecystokinin antagonist from Aspergillus alliaceus. Fermentation, isolation and biological properties. Goetz M.A. et al., J. Antibiot. 1985, 38, 1633.

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