Avermectin B1b

Avermectin B1b

Avermectin B1b

$350.00 - 0.5 mg

$1,225.00 - 2.5 mg

All prices in Australian dollars

Code
BIA-A1011
Synonyms
C 076B1b
CAS #
65195-56-4
Molecular Formula
C47H70O14
Molecular Weight
859.1
Purity
>95% by HPLC
Long Term Storage
-20°C
Solubility
Soluble in methanol, DMSO. Poor water solubility.

Download Data Sheets

Product Data Sheet

Application Notes

Avermectin B1b is the minor component (<20%) of a commercially available anthelmintic used to control parasitic nematodes in livestock. Avermectin B1b contains an isopropyl residue in the 25-position. In vitro and in vivo studies have shown this analogue to be active, but less potent than the B1a analogue

References

  • Avermectin B1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance. Fritz L.C. et al., et al., Proc Natl Acad Sci U S A. 1979, 76, 2062.
  • Solubilization and characterization of a high affinity ivermectin binding site from Caenorhabditis elegans.Cully D.F. et al., Mol Pharmacol. 1991, 40, 326.
  • Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics.Wolstenholme A.J. and Rogers A.T. Parasitology. 2005, 131, S85-95 (Review).

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