$341.00 - 0.50 mg
$1,194.00 - 2.50 mg
All prices in Australian dollars
- C 076B1b
- CAS #
- Molecular Formula
- Molecular Weight
- >95% by HPLC
- Long Term Storage
- Soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
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Avermectin B1b is the minor component (<20%) of a commercially available anthelmintic used to control parasitic nematodes in livestock. Avermectin B1b contains an isopropyl residue in the 25-position. In vitro and in vivo studies have shown this analogue to be active, but less potent than the B1a analogue
- Avermectin B1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by reducing muscle membrane resistance. Fritz L.C. et al., et al., Proc Natl Acad Sci U S A. 1979, 76, 2062.
- Solubilization and characterization of a high affinity ivermectin binding site from Caenorhabditis elegans.Cully D.F. et al., Mol Pharmacol. 1991, 40, 326.
- Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics.Wolstenholme A.J. and Rogers A.T. Parasitology. 2005, 131, S85-95 (Review).